Fresh analysis indicates that patients who come off new slimming jabs like semaglutide or tirzepatide can put back on lost weight far faster than those who end conventional lifestyle regimens.
Published data in a major medical journal points out that while overweight people frequently drop about a fifth of their body weight while undergoing treatment, the mass returns at an average rate of nearly a kilo each month upon discontinuation.
"Users purchasing such medications must be informed of the risk of rapid rebound weight gain when the therapy ends," cautioned researcher Dr. Susan Jebb.
That rate of regain means a return to original weight in about 18 months.
Comparing Approaches
The analysis, which looked at 37 of studies involving over 9,000 of patients, contrasted the effects of the injectable medications with conventional dieting.
Researchers emphasize that individuals who lose weight through diet and exercise typically have a slower weight regain—around 100 grams monthly—post-intervention.
Understanding the Rapid Rebound
Doctors believe the way of the injections is key to understanding the heightened rebound.
The injections imitate a body's own chemical called GLP-1, which controls hunger.
"Long-term administration of GLP-1 levels several times higher than normal might result in the system to produce less of its endogenous hormone, and could reduce sensitivity to its effects," noted Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this medication leads to appetite is no longer kept in check, making binge eating far more likely."
An Ongoing Issue?
Medical guidelines recommend the jabs for people with obesity-related health risks, alongside prescribed diet and exercise modifications.
A number of clinicians contend that, due to the significant potential of relapse, the therapy might need to be ongoing.
This opinion is reinforced by drug manufacturers, who state that the findings "underscore the chronic character of obesity," akin to managing diseases like hypertension.
User Experiences
Individuals who have discontinued the medication explain a sudden return of appetite.
"It felt as if a trigger flipping and you're instantly ravenous," described one woman.
This challenge is compounded if individuals have not established sustainable lifestyle or habit modifications during treatment.
Widespread Interest
Survey data suggest that millions of adults in the UK have tried weight-loss jabs in the past year, with desire being substantial.
- Adoption is greater among women compared to men.
- The middle-aged demographic shows the highest usage rates.
- Many access the medications through private healthcare rather than the NHS.
Ultimately, experts stress that while these medications are potent agents for shedding pounds, they are not a permanent solution and maintained weight loss relies on combined behavioural support.
